An inherent acceleratory effect of insulin on small intestinal transit and its pharmacological characterization in normal mice

Table 1 Effect of insulin administration on small intestinal transit and blood glucose levels in normal mice

Treatment Insulin (U/kg sc)	% SIT1	Blood glucose (%)2
Vehicle	52.06 ± 1.48	103.73 ± 4.19
2 μ	70.77 ± 0.62a	99.47 ± 1.59
2 m	73.53 ± 0.63a	94.54 ± 4.62
2	80.10 ± 1.93a	42.09 ± 1.78a

Each value represents the mean ± SE (n = 6) sc: subcutaneous; SIT: small intestinal transit;

^aP < 0.01 vs vehicle treated group;

¹Values are % SIT considering the total length of the intestine as 100, SIT was determined 40 min after insulin administration;

²Blood glucose was estimated 2 min before insulin/vehicle administration and 2 min before sacrificing the animals for the measurement of small intestinal transit (SIT), final blood glucose expressed as % considering the initial blood glucose of each animal as 100.