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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2006; 12(13): 2095-2102
Published online Apr 7, 2006. doi: 10.3748/wjg.v12.i13.2095
Published online Apr 7, 2006. doi: 10.3748/wjg.v12.i13.2095
Table 2 Effects of anti-adrenomedullin antibody on hemodynamics and aortic ring contraction of cirrhotic rats.
Vehicle | Anti-AM antibody | |
Hemodynamic effects | ||
Mean arterial pressure (mmHg) | 117 ± 3 | 121 ± 4 |
Cardiac index (mL/min·100g bw) | 39.5 ± 2.9 | 38.2 ± 3.8 |
Systemic vascular resistance (mmHg·min·100g bw/mL) | 3.1±0.4 | 3.4±0.4 |
Portal pressure (mmHg) | 13.0 ± 0.4 | 12.8 ± 0.5 |
Portal venous inflow (mL/min·100g bw) | 6.8 ± 0.8 | 5.6 ± 1.0 |
Portal venous system resistance (mmHg·min·100g bw/mL) | 2.2 ± 0.3 | 2.6 ± 0.4 |
Aortic ring contraction | ||
Rmax (mg/mg tissue) | 998 ± 96 | 1499 ± 137a |
EC50 (nmol/L) | 85.7 ± 11.8 | 53.8 ± 6.2 |
- Citation: Sakurai S, Kojima H, Uemura M, Satoh H, Fukui H. Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats. World J Gastroenterol 2006; 12(13): 2095-2102
- URL: https://www.wjgnet.com/1007-9327/full/v12/i13/2095.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i13.2095