Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats

Table 1 Hemodynamic effects of chronic administration of adrenomdullin in control rats

	Vehicle (n=8)	AM (n=8)	Pvalue
Mean arterial pressure (mmHg)	132 ± 3	122 ± 4	< 0.05
Cardiac index (mL/min·100g bw)	26.0 ± 2.1	34.1 ± 2.	< 0.05
Systemic vascular resistance (mmHg·min·100g bw/mL)	5.3  ± 0.4	3.8 ± 0.4	< 0.05
Portal pressure (mmHg)	6.9 ± 0.5	7.0 ± 0.5	NS
Portal venous inflow (mL/min·100g bw)	3.5 ± 0.4	5 .0 ± 0.6	< 0.05
Portal venous system resistance (mmHg·min·100g bw/mL)	2.1 ± 0.3	1.6 ± 0.3	NS
Splanchnic arterial resistance (mmHg·min·100g bw/mL)	38.5 ± 4.1	25.7 ± 4.0	< 0.05

Control rats were chronically infused with either vehicle or human adrenomedullin (AM) (1.0 mg/h) for 14 d using mini-osmotic pump. On day 14 of chronic infusion, hemodynamic study was performed using radioactive microspheres. Values are presented as mean ± SE of 8 separate experiments.