Cryptogenic cirrhosis in the region where obesity is not prevalent

doi:10.3748/wjg.v12.i13.2080

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Apr 7, 2006 (publication date) through Jul 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2006; 12(13): 2080-2085
Published online Apr 7, 2006. doi: 10.3748/wjg.v12.i13.2080

Table 1 Characteristics of cryptogenic cirrhotic patients and matched controls

	Cryptogenic(n=24)	Control; all(n=72)	HCV-related(n=48)	HBV-related(n=24)
Age (yr)	58.2 ± 10.6	58.6 ± 8.8	58.7 ± 8.1	58.3 ± 10.2
Child-Pugh score	6.3 ± 1.4	6.5 ± 1.2	6.5 ± 1.2	6.4 ± 1.3
Follow-up (yr)	5.7 ± 4.2	5.9 ± 4.4	6.5 ± 4.2	4.7 ± 4.5
Transfusion (%)	0	26.8 ^b	34.0 ^b	12.5
Body mass index (kg/m²)	25.5 ± 3.2	22.4 ± 3.0 ^b	22.6 ± 3.3 ^b	22.0 ± 2.4 ^b
ICGR15 (%)	31.5 ± 16.7	27.2 ± 12.3	28.2 ± 12.1	25.0 ± 12.7
Total bilirubin (mmol/L)	22 ± 15	21 ± 10	22 ± 10	19 ± 10
AST (nkat/L)	959 ± 572	1349 ± 772 ^a	1410 ± 573 ^b	1229 ± 1064
ALT (nkat/L)	860 ± 640	1229 ± 765 ^a	1359 ± 748 ^b	972 ± 747
AKP (nkat/L)	6518 ± 2942	6638 ± 2976	6695 ± 2577	6529 ± 3692
Albumin (g/L)	40 ± 5	38 ± 5	38 ± 5 ^b	38 ± 6
γ-globulin (g/L)	17 ± 3	18 ± 5	19 ± 4	15 ± 5
Cholinesterase (U/L)	242.8 ± 118.2	174.5 ± 67.8 ^b	162.1 ± 61.7 ^b	198.8 ± 73.7
Total cholesterol (mg/dL)	170.5 ± 43.0	156.5 ± 35.1	151.2 ± 31.3 ^b	166.8 ± 40.2
Triglyceride (mg/dL)	103.8 ± 44.2	83.0 ± 25.5 ^b	84.5 ± 26.6 ^b	80.1 ± 23.8 ^b
Prothrombin time (INR)	1.15 ± 0.15	1.19 ± 0.14	1.21 ± 0.14	1.16 ± 0.14
Hemoglobin A1c (%)	6.2 ± 1.3	5.1 ± 0.8 ^b	5.3 ± 0.9 ^a	4.8 ± 0.7 ^b
Blood glucose (mg/dL)	123.1 ± 48.2	96.4 ± 21.0 ^b	96.9 ± 23.0 ^b	95.2 ± 16.3 ^a
Insulin (mU/L)	26.8 ± 15.7	14.2 ± 6.4 ^b	15.9 ± 6.6 ^b	10.8 ± 4.5 ^b
HOMA-R (%)	8.6 ± 4.8	3.6 ± 2.5 ^b	4.0 ± 2.9 ^b	2.6 ± 1.3 ^b
QUICKI	0.29 ± 0.02	0.33 ± 0.03 ^b	0.32 ± 0.02 ^b	0.34 ± 0.04 ^b
Transferrin saturation (%)	36.3 ± 17.5	45.2 ± 29.7	48.5 ± 31.1	40.0 ± 27.8
Ferritin (mg/L)	160.0 ± 155.3	193.5 ± 282.9	225.0 ± 318.1	99.3 ± 104.8
Visceral fat area (cm²)	102.0 ± 39.8	56.9 ± 35.3 ^b	52.1 ± 30.7 ^a	64.3 ± 43.9 ^b
Liver/spleen ratio	1.08 ± 0.05	1.08 ± 0.06	1.07 ± 0.06	1.09 ± 0.06

^aP < 0.05, ^bP < 0.01 vs cryptogenic cirrhosis. ICGR15:indocyanine green retention rate, INR:international normalized ratio, HOMA-R:homeostasis model assessment parameter of insulin resistance, QUICKI: quantitative insulin check index.

Citation: Kojima H, Sakurai S, Matsumura M, Umemoto N, Uemura M, Morimoto H, Tamagawa Y, Fukui H. Cryptogenic cirrhosis in the region where obesity is not prevalent. World J Gastroenterol 2006; 12(13): 2080-2085
URL: https://www.wjgnet.com/1007-9327/full/v12/i13/2080.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i13.2080