Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells

Figure 3 Role of PI3K, Src or JAK2 pathways in human colonic tumour cell proliferation induced by G-gly. Serum-starved HCT116 cells were treated with G-gly for 48h in the presence or absence of the indicated inhibitor (10 µmol/L). The proliferation was determined as described in Methods. Each point represents data from triplicate and is representative of 5 independent experiments. Data are presented as means ± SE.