Expression of cytokeratins in Helicobacter pylori –associated chronic gastritis of adult patients infected with cagA+ strains: An immunohistochemical study

Table 3 Expression of CK18 in antral mucosa of patients with gastritis (H pylori positive and negative) compared to the control group

Cytokeratin 18expression	Antral mucosa epithelium
	H pylori+G		H pylori-G		CG		P
	n	%	n	%	n	%
Surface epithelium
Diffuse immunoreactivity	32	56.1	14	82.3	5	50.0	NS
Focal immunoreactivity	24	42.1	2	11.8	3	30.0	NS
Without staining	1	1.7	1	5.9	2	20.0	0.043
n (%)	57	100	17	100	10	100
Foveolar epithelium
Diffuse immunoreactivity	31	54.4	8	47.1	1	10	0.035
Moderate/Strong	30	52.7	8	47.1	1	10	0.045
Weak	1	1.7	0	0	0	0	NS
Focal immunoreactivity	20	35.1	1	5.8	0	0	0.008
Moderate/Strong	5	8.8	0	0	0	0	NS
Weak	15	26.3	1	5.8	0	0	0.045
Without staining	6	10.5	8	47.1	9	90	<0.001
n (%)	57	100	17	100	10	100
Glandular necks
Diffuse immunoreactivity	36	63.2	13	76.5	6	60	NS
Focal immunoreactivity	18	31.6	2	11.8	2	20	NS
Without staining	3	5.2	1	5.9	2	20	NS
n (%)	57	100	17	100	10	100
Deep glands
Diffuse immunoreactivity	15	26.3	8	47.0	4	40	NS
Moderate/Strong	15	26.3	5	29.4	3	30	NS
Weak	0	0	3	17.6	1	10	0.008
Focal immunoreactivity	18	31.6	3	17.7	4	40	NS
Without staining	24	42.1	6	10.3	2	20	NS
n (%)	57	100	17	100	10	100

CG:control group; H pylori+G -:Helicobacter pylori positive patients with gastritis; H pylori-G: Helicobacter pylori negative patients with gastritis; NS: P > 0.05