Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage II and III rectal adenocarcinoma: The Freiburg experience (1989-2002)

Table 5 Results of uni- and multivariate analysis (other variables)

	OAS	CSS	DFS	LRS	DRS
N stage
uni- / multivariate: P =	0.009 / NS	0.05 / NS	0.06 / NS	0.09 / NS	0.15 / NS
CEA
uni- / multivariate: P =	< 0.001 / 0.007	< 0.001 / NS	< 0.001 / 0.001	< 0.001 / NS	0.55 / 0.055
multivariate risk ratio:	CEA increase: 1.37		CEA increase: 3.21		CEA decrease: 0.91
	(CI 1.09 – 1.73)		(CI 1.61 – 6.82)		(CI 0.76 – 1.00)
CA 19-9
uni- / multivariate: P =	< 0.001 / NS	0.033 / NS	0.22 / NS	0.79 / NS	0.62 / NS
Tumor location
uni- / multivariate: P =	0.34 / NS	0.43 / NS	0.4 / NS	0.83 / NS	0.37 / NS
Adherence to adjacent structures
uni- / multivariate: P =	< 0.001 / NS	0.004 / NS	< 0.001 / NS	0.13 / NS	0.019 / NS
BMI before RT
uni- / multivariate: P =	0.47 / NS	0.55 / NS	0.83 / NS	0.83 / NS	0.15 / NS
Smoking
uni- / multivariate: P =	0.79 / NS	0.49 / NS	0.71 / NS	0.22 / NS	0.31 / NS
Hkt before vs after RT
uni- / multivariate: P =	0.047 / NS	0.35 / NS	0.31 / NS	0.87 / NS	0.99 / NS
LDH before vs after RT
uni- / multivariate: P =	0.32 / NS	0.69 / NS	0.77 / NS	0.37 / NS	0.21 / NS

Risk ratio with confidence interval (CI) is given if multivariate analysis (step down analysis) revealed a significant result. Five- and 10- year survival rates are given as OAS, CSS, DFS, LRS and DRS