Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage II and III rectal adenocarcinoma: The Freiburg experience (1989-2002)

Table 4 Survival rates and results of uni- and multivariate analysis (treatment-related variables)

		OAS (%)	CSS (%)	DFS(%)	LRS (%)	DRS (%)
Adjuvant therapy
Postop RCT	5 yr / 10 yr:	47.6 / 35.6	59.0 / 48.4	40.2 / 34.0%	66.1 / 64.1	82.2 / 82.2
Preop RCT	5 yr / 10 yr:	43.9 / 38.0	62.6 / 62.6	45.4 / 39.3	69.8 / 69.8	92.8 / 92.8
	uni- / multivariate: P =	0.82 / NS	0.56 / NS	0.61 / NS	0.96 / NS	0.12 / NS
Protocol
NIH	5 yr / 10 yr:	60.7 / 45.2	72.5 / 59.4	49.8 / 44.2	84.1 / 84.1	73.2 / 73.2
ARO	5 yr / 10 yr:	26.9 / 21.5	45.6 / 36.5	24.5 / 16.3	67.6 / 67.6	64.0 / 64.0
	uni- / multivariate: P =	< 0.001 / NS	0.003 / 0.004	0.002 / NS	0.024 / NS	0.57 / NS
	multivariate risk ratio:		ARO: 2.66
			(CI 1.37 – 5.21)
Surgery	risk ratio:
LAR	5 yr / 10 yr:	36.4 / 25.9	49.5 / 41.1	27.8 / 22.7	64.7 / 64.7	81.3 / 81.3
APR	5 yr / 10 yr:	35.2 / 26.0	46.7 / 39.9	27.6 / 22.9	52.4 / 51.1	86.4 / 86.4
	uni- / multivariate: P =	0.4 / NS	0.51 / NS	0.27 / NS	0.015 / 0.039	0.6 / NS
	multivariate risk ratio:				LAR: 1.3
					(CI 1.01 – 1.60)
R status
R0	5 yr / 10 yr:	53.2 / 40.3	64.2 / 55.1	45.6 / 39.5	66.2 / 64.5	91.2 / 91.2
R1 or R2	5 yr / 10 yr:	14.2 / 14.2	20.7 / 20.7	17.3 / 17.3	62.9 / 62.9	51.2 / 51.2 5
	uni- / multivariate: P =	< 0.001 / NS	0.011 / (0.09)	< 0.001 / 0.026	0.95 / NS	< 0.001 / NS
	multivariate risk ratio:		R1/R2: 1.65	R1/R2: 3.45
			(CI 0.91 – 3.10)	(1.56 – 7.96)

Risk ratio with confidence interval (CI) is given if multivariate analysis (step down analysis) revealed a significant result. Five- and 10- year survival rates are given as OAS, CSS, DFS, LRS and DRS.