Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage II and III rectal adenocarcinoma: The Freiburg experience (1989-2002)

Table 3 Survival rates and results of uni- and multivariate analysis (patient-related variables)

		OAS (%)	CSS (%)	DFS(%)	LRS (%)	DRS (%)
All stages II & III	5 yr / 10 yr:	47.0 / 36.0	60.0 / 52.0	41.4 /34.9	67.2 / 65.7	84.3 / 84.3
	at risk (5 yr / 10 yr):	78 / 34	81 / 36	69 / 34	72 / 46	74 / 34
	median survival:	1602		996
Gender
Male	5 yr / 10 yr:	49.2 / 36.3	64.9 / 56.8	24.7 / 12.9	73.1 / 73.1	85.1 / 85.1
Female	5 yr / 10 yr:	43.2 / 37.0	51.7 / 44.3	21.0 / 8.0	56.8 / 53.0	83.2 / 83.2
	uni- / multivariate: P =	0.93 / NS	0.16 / NS	0.17 / NS	0.01 / 0.018	0.66 / NS
	multivariate risk ratio:				male: 0.75
					(CI 0.59 – 0.95)
Age
< 62 yr	5 yr / 10 yr:	52.2 / 42.0	62.0 / 55.8	31.1 / 16.0	65.3 / 63.4	85.9 / 85.9
> 62 yr	5 yr / 10 yr:	41.0 / 27.0	57.1 / 42.6	13.6 / 5.1	70.4 / 70.4	80.2 / 80.2
*Median age	uni- / multivariate: P =	0.02 / NS	0.22 / 0.005	< 0.01 / NS	0.47 / NS	0.59 / NS
	multivariate risk ratio:		< 61 yr: 0.48
			(CI 0.28 – 0.80)
Staging
II	5 yr / 10 yr:	57.0 / 49.9	65.8 / 62.5	53.3 / 45.5	75.1 / 75.1	85.5 / 85.5
III	5 yr / 10 yr:	42.6 / 30.2	57.2 / 47.4	36.3 / 28.7	63.3 / 61.0	83.8 / 83.8
	uni- / multivariate: P =	0.02 / NS	0.09 / 0.009	0.02 / NS	0.06 / (0.07)	0.7 / NS
	multivariate risk ratio:		stage II: 0.45		stage II: 0.79
			(CI 0.21 – 0.84)		(CI 0.59 – 1.03)
Grading
II	5 yr / 10 yr:	50.6 / 39.7	62.0 / 55.1	49.3 / 41.7	73.3 / 70.7	86.8 / 86.8
III	5 yr / 10 yr:	40.7 / 36.6	55.3 / 49.8	23.3 / 23.3	58.8 / 58.8	64.4 / 64.4
	uni- / multivariate: P =	0.023 / (0.06)	0.07 / NS	< 0.01 / NS	0.04 / NS	< 0.01 / 0.04
	multivariate risk ratio:	G III: 1.68				G III: 2.87
		(CI 0.97 – 2.78)				(CI 1.08 – 7.01)

Risk ratio with confidence interval (CI) is given if multivariate analysis (step down analysis) revealed a significant result. Five- and 10- year survival rates are given as OAS, CSS, DFS, LRS and DRS.