Sporadic somatic mutation of c-kit gene in a family with gastrointestinal stromal tumors without cutaneous hyperpigmentation

Figure 3 A. Direct sequencing analysis of DNA from peripheral leukocyte obtained from patients 1 and 2 revealed no mutation in exon 11 of c-kit gene; B. Direct sequencing analysis of DNA from patient 1 showed deletion mutation at codon 560 in exon 11, causing a deletion mutant 560 del V; C. Direct sequencing analysis of DNA from patient 2 revealed deletion at codons 557-559 in exon 11, resulting in replacement of WKV by C.