Sporadic somatic mutation of c-kit gene in a family with gastrointestinal stromal tumors without cutaneous hyperpigmentation

Figure 2 A: Abdominal CT revealed gastric GIST at the anterior wall and greater curvature side of high body of the stomach; B: Microscopic findings of the tumor resected. Tumor cells were composed of resicular spindle cells with mild nuclear pleomorphism but no necrosis, expressing strong positive c-kit staining immunohistochemically. (IHC staining, 200X); C: Abdominal CT revealed a gastric GIST measuring 13 cm x 10 cm in size occupying the whole stomach. D: Microscopic findings of the tumor resected. Tumor comprised proliferation of spindle cells with mild nuclear atypia in the mxyoid stroma but no necrosis, expressing positive c-kit staining. (IHC staining, 200X).