Cerebral processing of auditory stimuli in patients with irritable bowel syndrome

Table 2 Significant activations (signal increase) and deactivations (signal decrease) induced by different acoustic stimuli

I) PEEP			1Largest cluster
A: Control deactivation
RoI	Side	No. of	No. of	x1	y1	z1	% signal
		Clusters	Voxels1				change*
ACC	L	1	-793	-8	37	-10	-0.53
PFC	B	7	-1506	37	35	-7	-0.52
B: IBS deactivation
ACC	L	1	-271	-6	31	7	-0.28
PFC	B	7	-1724	23	57	8	-0.52
Amyg - dala	R	1	-452	25	1	-20	-0.33
HC	B	2	-436	33	-22	-24	-0.38
II) CHIMES
A: Control activation
ACC	B	1	699	-1	29	2	0.40
PFC	B	7	1957	-4	37	-6	0.39
Deactivation
PFC	B	4	-1781	31	47	23	-0.48
PCC	L	1	-707	-5	-4	51	-0.24
Insula	R	1	-850	32	1	7	-0.25
HC	R	1	-113	26	-14	-15	-0.14
B: IBS deactivation
ACC	B	2	-1212	2	18	44	-0.38
PCC	B	1	-159	0	-17	32	-0.36
PFC	R	3	-2095	54	13	13	-0.42
III) EMOTIONAL WORDS			1Largest cluster
A: Control deactivation
ACC	L	1	-724	-5	36	13	-0.33
PFC	B	4	-275	-4	47	-2	-0.36
PCC	L	1	-134	-1	-33	44	-0.35
PSAC	B	1	-2048	0	-62	33	-0.36
HC	R	1	-31	25	-24	-15	-0.21
B: IBS activation
PFC	L	1	609	-46	29	-1	0.25
Deactivation
ACC	R	1	-1207	2	40	5	-0.41
PFC	B	4	-2076	9	43	26	-0.32
PSAC	B	1	-2048	0	-46	42	-0.35
HC	B	2	-1010	24	-35	-12	-0.29
Insula	R	1	-331	34	-10	1	-0.19
IV) NEUTRAL WORDS
A : Controls activation
PFC	R	1	45	26	55	6	0.40
PSAC	R	1	45	26	-42	53	0.05
Deactivation
ACC	L	1	-118	-3	31	-6	-0.44
B : IBS activation
ACC	R	2	223	1	6	46	0.19
PFC	B	8	1408	0	46	-11	0.18
PSAC	B	4	257	26	-65	41	0.08
HC	B	2	652	27	-27	19	0.14
PCC	L	2	102	-2	-39	37	0.12

RoI= region of interest, R=right, L=left, B= bilateral, ACC= anterior cingulate cortex, PCC= Posterior Cingulate Cortex, PFC=prefrontal cortex, PSAC=parietal sensory association cortex, HC=hippocampus, x+y+z=coordi- nates of the Talairach space.