Relaxin prevents the development of severe acute pancreatitis

Figure 4 Apoptosis versus necrosis. A: Blood lactate dehydrogenase. As a marker of cellular injury and death significant high blood levels of LDH for groups 3&4 ^aP < 0.005 reflected the undergoing severe AP while groups 10&12 presented a significant reduction in the enzyme value ^cP < 0.005. Homogenous. Groups for LDH are:1-2-(12-10)-8-9-11-(5-6-7)-(3-4), P < 0.005. B-D: ATP concentration. The significant decrease in ATP concentration that surpassed the 80% loss for groups 3&4 ^aP<0.005,is the hallmark of the necrotic process that is being developed while groups 10&12 that underwent apoptosis did not manifest such extreme values ^cP<0.005. This expression in the nucleotide levels is translated into the ADP/ATP ratio that is significantly increased ^aP<0.01 for groups 3&4 that underwent necrosis while groups 10&12 that underwent apoptosis had significantly lower values ^cP<0.05. Homogenous Groups are: 1-2-(12-10)-8-9-11-(5-6-7)-(3-4), P<0.005. Results are shown as mean ± SD.