Relaxin prevents the development of severe acute pancreatitis

Table 1 Pancreatic and general biochemical assays in blood (mean ± SD)

Groups	Amylase	Lipase	Glucose	Urea	Creatinine	Calcium	Proteins	AST	ALT	Hto
	IU/L	IU/L	mg/dL	mg/dL	mg/dL	mg/dL	g/L	IU/L	IU/L	%
1 Basal	1103 ± 108	85 ± 18	92 ± 13	29 ± 3	0.35 ± 0.04	13.48 ± 0.39	85.5 ± 1.2	177 ± 25	88 ± 19	39 ± 5
2 Surgery control	1198 ± 114	98 ± 10	95 ± 10	38 ± 5	0.48 ± 0.11	13.22 ± 0.35	82.7 ± 0.8	205 ± 21	99 ± 21	31 ± 4
3 AP	7915 ± 159	5619 ± 194	338 ± 24	219 ± 19	1.82 ± 0.21	8.92 ± 0.16	61.1 ± 1.3	589 ± 26	295 ± 28	49 ± 9
4 AP+PBS	7921 ± 137	5628 ± 201	341 ± 19	217 ± 15	1.81 ± 0.16	8.94 ± 0.20	61.2 ± 2.2	591 ± 25	299 ± 28	49 ± 8
5 Rlx+LN	7154 ± 165	4982 ± 203	246 ± 23	183 ± 22	1.58 ± 0.22	9.37 ± 0.18	65.5 ± 1.8	544 ± 30	268 ± 19	47 ± 6
6 Rlx+MIF	7162 ± 171	4997 ± 207	249 ± 27	185 ± 24	1.60 ± 0.25	9.35 ± 0.14	65.1 ± 1.9	552 ± 28	270 ± 22	47 ± 8
7 Rlx+LN+MIF	7548 ± 175	5327 ± 214	262 ± 33	194 ± 21	1.69 ± 0.22	9.11 ± 0.21	62.4 ± 1.4	563 ± 34	281 ± 27	48 ± 5
8 Rlx 1h pre	6052 ± 169	3618 ± 155	190 ± 16	125 ± 11	1.13 ± 0.14	11.19 ± 0.22	74.5 ± 2.3	405 ± 24	196 ± 23	40 ± 4
9 Rlx 1h post	6427 ± 185	3910 ± 183	218 ± 15	146 ± 15	1.24 ± 0.19	10.91 ± 0.19	71.1 ± 1.9	452 ± 37	211 ± 27	45 ± 4
10 Rlx 1h pre+4h post	5589 ± 129	3161 ± 142	166 ± 18	97 ± 8	1.02 ± 0.17	11.98 ± 0.24	79.4 ± 1.6	382 ± 29	178 ± 23	42 ± 5
11 Rlx 4h post	6896 ± 192	4533 ± 178	235 ± 29	165 ± 19	1.39 ± 0.20	10.21 ± 0.19	69.9 ± 2.1	497 ± 33	235 ± 25	46 ± 5
12 Rlx 12h&1h pre+4h post	5535 ± 144	3153 ± 121	162 ± 22	95 ± 10	1.00 ± 0.15	12.03 ± 0.29	79.8 ± 1.4	395 ± 33	171 ± 25	43 ± 5

In relationship to Reference Basal-Group 1, BPDOE-CDLs AP-Group 3 presents a significant difference in all the assays evaluated P<0.05. The pancreatic and general biochemical profile significantly improved with relaxin treatment particularly for Groups 10 &12 that corresponded to administration times 12h and/or 1h pre and 4h post surgery P<0.05. Homogenous groups for amylase and lipase:1-2-(12-10)-8-9-11-(5-6-7)-(3-4), P<0.05. HTO: hematocrite, Rlx: relaxin, LN: L-NAME, MIF: mifepristone.