Role of radiation therapy in gastric adenocarcinoma

Table 5 Treatment results: Unresectable or residual gastric cancer

Reference	n	Treatment	Radiation therapy	Chemotherapy	Results
Randomized
Mayo Clinic[51]	48	EBRT ± CT	35-37.5 Gy in 4-5 wk	5FU 1st wk of EBRT	Median survival 13 vs 6 mo and 5-year overall survival 12% vs 0% favoringEBRT+5FU
GITSG[53]	90	CT ± EBRT	50 Gy split course in 8 wk	5FU during EBRT, maintenance 5FU/MeCCNU	4-year survival 18% vs 7%, favoring CT+EBRT
EORTC[52]	90	EBRT ± CT	55.5 Gy in 6 wk	5FU	14% long-term survival (3 patients) with EBRT and 5FU
Retrospective
MGH[55]	32	EBRT ± CT	45-55 Gy in 5-6 wk	5FU during EBRT, maintenance 5FU/MeCCNU	EBRT+CT: Unresectable disease 14 mo median survival; unresectable and residual disease 10% 4-year survival

Abbreviations: EBRT=external beam radiation therapy; CT = chemotherapy; 5FU = 5-fluorouracil; MeCCNU = semustine; GITSG = gastrointestinal study group; EORTC=European organization for research and treatment of cancer; MGH=Massachusetts General Hospital; Gy=gray.