Role of radiation therapy in gastric adenocarcinoma

Table 2 Randomized trials of adjuvant radiation therapy in gastric carcinoma

		Survival		Local-regional relapse
Reference	n	Median (mo)	5-year (%)	P value	%	P value
Mayo Clinic[14]
Surgery alone	23	15	4	0.05	54	NS
Post-op EBRT + CT	39	24	23		39
British stomach group[11,12]
Surgery alone	145	15	20	NS	27	<0.01 for
Post-op CT	138	13	19		19
Post-op EBRT	153	17	12		10	EBRT
China-Beijing[13]
Surgery alone	199	NR	20	0.009	521	<0.025
Pre-op EBRT	171	NR	30		39
Intergroup 0116[16]
Surgery alone	275	27	41 (3 yr)	0.005	29	NR
Postop EBRT + CT	281	36	50 (3 yr)		19
Walsh et al[15]
Surgery alone	55	11	6 (3 yr)	0.01	NR	-
Preop EBRT + CT	58	16	32 (3 yr)

Abbreviations: CT = chemotherapy, EBRT = external beam radiation therapy, NS = not significant, NR = not reported.

¹Refers to local relapse. Regional relapse with 54% with surgery alone versus 39% with chemoradiation, P < 0.05.