A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats

Table 1 Effect of post-AA administration on gastric mucosal lesion development in rats with a single C48/80 treatment.

Time after C48/80 treatment and groups	Lesion index (%)								P (vsC48/80 at 3 h)	P (vsC48/80 at 0.5 h)
	0	I	II	III	IV	V	VI	VII
0.5 h C48/80	0	20	50	30	0	0	0	0	¯	¯
3 h C48/80	0	0	0	0	0	20	40	40	¯	0.05
+ AA (10 mg/kg)	0	0	0	0	10	30	50	10	NS	0.05
+ AA (50 mg/kg)	0	0	0	30	40	30	0	0	0.05	0.05
+ AA (100 mg/kg)	0	0	40	50	10	0	0	0	0.05	NS

Rats received oral administration of AA (10, 50 or 100 mg/kg) or vehicle at 0.5 h after a single intraperitoneal injection of compound 48/80 80.75 mg/kg) and the severity of gastric mucosal lesions was estimated at 0.5 and 3 h after the compound 48/80 injection. The number of rats used in each group was 10. NS indicates not significant.