Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed

doi:10.3748/wjg.v11.i9.1267

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Mar 7, 2005 (publication date) through Nov 7, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Mar 7, 2005; 11(9): 1267-1272
Published online Mar 7, 2005. doi: 10.3748/wjg.v11.i9.1267

Table 1 Covering BAC clones and position of 13 genes and sequence of Q-PCR primers of LINE1 and 13 genes over 3q25.3-qter.

Genes	BAC clones	Position	Forward primer	Reverse primer
LINE1	-	-	CCGCTCAACTACATGGAAACTG	GCGTCCCAGAGATTCTGGTATG
SSR3	304C15	3q25.31	GCCCAGGCATATGAGAGTTGTC	CCAACATGGCAGGGTCAAGT
CCNL1	6F2	3q25.31	TCATGGCAGTCAACCAACAT	CCATTGTAAGGGCTTTTGGA
SMC4L1	227J5	3q26.1	GGCAAAGTCCTAAGCAAGGTTGT	TCAACTGGCAAGCTAAGTGGAA
EVI1	141C22	3q26.2	CATGCATGCTGATTGCAGAAC	CCACCTGCCGCAAAATGGT
hTERC	40O08	3q26.2	CGTAGGCGCCGTGCTTT	TTTTCCGCCCGCTGAA
SKIL	543D10	3q26.2	GCTCGGCATTCCCAAGAAA	CCCCTTCCAACACAGTCTGAGT
EIF5A2	110O7	3q26.2	GGCTTCCAGCACTTACCCTATG	GACCATGCTTTCCAGTTTTGG
ECT2	453J16	3q26.31	CCTAACAGCAATCGCAAACG	CTGTCTCTCTTGAAAGCTGAGCAA
PIK3CA	245C23	3q26.32	GGAGGATGCCCAATTTGATG	AACAGTCCATTGGCAGTTGAGA
EIF4G1	481O2	3q27.1	CCGGTTCCAGAATCTGAGTTTT	GATTCGGAGGGGCAAGCTG
SST	211G3	3q27.3	GATGCCCTGGAACCTGAAGA	GCCGGGTTTGAGTTAGCAGAT
TP63	313I6	3q28	CCTCGTCCACCAGTCCCTAT	GGAAGGACACGTCGAAACTG
TFRC	313F11	3q29	CAAAGTGGCACGAGCAGCTG	GCTCTAGAATGAACGGTGGAAG

LINE1: long interspersed elements; SSR3: signal sequence receptor gamma; CCNL1: cyclin L1; SMC4L1:structural maintenance of chromosomes 4-like 1; EVI1: ecotropic viral integration site 1; hTERC: human telomerase RNA component; SKIL: Ski-like protein; EIF5A2: eukaryotic translation initiation factor 5A2; ECT2: epithelial cell transforming sequence 2 oncogene; PIK3CA: phosphoinositide-3-kinase, catalytic, alpha polypeptide; EIF4G1: eukaryotic translation initiation factor 4gamma1; SST: somatostatin; TP63:tumor protein 63; TFRC: transferrin receptor. BAC clones, clones of bacterial artificial chromosomes covering the genes obtained from RPCI-11 library.

Citation: Yen CC, Chen YJ, Pan CC, Lu KH, Chen PCH, Hsia JY, Chen JT, Wu YC, Hsu WH, Wang LS, Huang MH, Huang BS, Hu CP, Chen PM, Lin CH. Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed. World J Gastroenterol 2005; 11(9): 1267-1272
URL: https://www.wjgnet.com/1007-9327/full/v11/i9/1267.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i9.1267