Effect of endothelin-1 receptor antagonists on histological and ultrastructural changes in the pancreas and trypsinogen activation in the early course of caerulein-induced acute pancreatitis in rats

Figure 2 Ultrastructural changes in the pancreatic acinar cells in untreated caerulein-induced AP. A: Dilated channels of rough endoplasmic reticulum and slightly damaged mitochondria (M) in the cytoplasm of the acinar cells. In the vicinity of nucleus, a vacuole (V) is seen. Original magnification ×3000, bar = 2.5 μm; B: Zymogen granules of different shape and size and dilated cisternae of the Golgi apparatus (G). Original magnification ×7000, bar = 1.1 μm.