A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis

Figure 8 Effect of PN50 on pancreatic morphological damage in CCK-induced pancreatitis. A: group PS (control group): normal pancreas (HE ×100); B: group CCK: marked edema, inflammatory activity, stasis (HE ×100); microfocal necroses, vacuolar degenerations in the acinar cells (insert: HE ×250); C: group PN50+CCK: mild inflammation, mild edema, fairly maintained parenchymal structure (HE ×100); mild degenerative changes in the acini (insert: HE ×250); D: group CCK+PN50: mild edema, minimal inflammatory activity (HE ×100); degenerative changes with apoptotic cells (arrows) in the acini (insert: HE ×250).