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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Feb 21, 2005; 11(7): 964-969
Published online Feb 21, 2005. doi: 10.3748/wjg.v11.i7.964
Published online Feb 21, 2005. doi: 10.3748/wjg.v11.i7.964
Table 1 Histological differentiation, invasion and Tie-1, 2 and Ang-1, 2, 4 expressions in human colorectal adenocarcinoma (n = 96), n (%).
n | Tie-1 | Tie-2 | Ang-1 | Ang-2 | Ang-4 | |||||||||||
- | + | ++ | - | + | ++ | - | + | ++ | - | + | ++ | - | + | ++ | ||
Adenoma | 11 | 7 (63.6) | 3 (27.3) | 1 (9.1) | 6 (54.5) | 3 (27.3) | 2 (18.1) | 7 (63.6) | 3 (27.3) | 1 (9.1) | 7 (63.6) | 3 (27.3) | 1 (9.1) | 8 (72.2) | 3 (27.3) | 0 (0.0) |
Total carcinoma | 96 | 9 (9.4) | 24 (25.0) | 63 (65.6) | 4 (4.2) | 25 (26.0) | 67 (69.8) | 13 (13.5) | 25 (26.0) | 58 (60.4) | 7 (7.3) | 23 (24.0) | 66 (69.0) | 20 (20.8) | 27 (28.1) | 49 (51.0) |
Histological differentiation | P = 0.000123 | P = 0.002209 | P = 0.000161 | NS | P = 0.008193 | |||||||||||
Ca in adenoma | 18 | 3 (16.7) | 8 (44.4) | 7 (38.9) | 1 (5.6) | 7 (38.9) | 10 (55.6) | 6 (33.3) | 7 (38.9) | 5 (27.8) | 3 (16.7) | 4 (22.2) | 11 (61.1) | 6 (33.3) | 7 (38.9) | 5 (27.8) |
Well | 29 | 5 (17.2) | 7 (24.1) | 17 (58.6) | 2 (6.9) | 12 (41.4) | 15 (51.7) | 4 (13.8) | 7 (24.1) | 18 (62.1) | 2 (6.9) | 7 (24.1) | 20 (69.0) | 7 (24.1) | 7 (24.1) | 15 (51.7) |
Moderate | 38 | 0 (0.0) | 7 (18.4) | 31 (81.6) | 0 (0.0) | 5 (13.2) | 33 (86.8) | 2 (5.3) | 8 (21.1) | 28 (73.7) | 1 (2.6) | 8 (21.1) | 29 (76.3) | 3 (7.9) | 11 (28.9) | 24 (63.2) |
Poor | 6 | 0 (0.0) | 0 (0.0) | 6 (100.0) | 0 (0.0) | 1 (16.7) | 5 (83.3) | 0 (0.0) | 0 (0.0) | 6 (100.0) | 0 (0.0) | 2 (33.3) | 4 (66.7) | 1(16.7) | 1 (16.7) | 4 (66.7) |
Mucinous | 5 | 1 (20.0) | 2 (40.0) | 2 (40.0) | 1 (20.0) | 0 (0.0) | 4 (80.0) | 1 (20.0) | 3 (60.0) | 1 (20.0) | 1 (20.0) | 2 (40.0) | 2 (40.0) | 3 (60.0) | 1 (20.0) | 1 (20.0) |
Depth of tumor invasion | P = 0.000473 | P = 0.006137 | P = 0.000747 | P = 0.0097 | P = 0.000949 | |||||||||||
Tis | 20 | 4 (20.0) | 9 (45.0) | 7 (35.0) | 2 (10.0) | 7 (35.0) | 11 (55.0) | 7 (35.0) | 8 (40.0) | 5 (25.0) | 3 (15.0) | 6 (30.0) | 11 (55.0) | 7 (35.0) | 8 (40.0) | 5 (25.0) |
T1 | 8 | 3 (37.5) | 3 (37.5) | 2 (25.0) | 1 (12.5) | 5 (62.5) | 2 (25.0) | 4 (50.0) | 3 (37.5) | 1 (12.5) | 2 (25.0) | 3 (37.5) | 3 (37.5) | 6 (75.0) | 1 (12.5) | 1 (12.5) |
T2 | 10 | 0 (0.0) | 2 (20.0) | 8 (80.0) | 0 (0.0) | 2 (20.0) | 8 (80.0) | 0 (0.0) | 2 (20.0) | 8 (80.0) | 0 (0.0) | 4 (40.0) | 6 (60.0) | 1 (10.0) | 4 (40.0) | 5 (50.0) |
T3 | 37 | 1 (2.7) | 6 (16.2) | 30 (81.1) | 0 (0.0) | 9 (24.3) | 28 (75.7) | 2 (5.4) | 5 (13.5) | 30 (81.1) | 1 (2.7) | 7 (18.9) | 29 (78.4) | 4 (10.8) | 7 (18.9) | 26 (70.3) |
T4 | 21 | 1 (4.8) | 4 (19.0) | 16 (76.2) | 1 (4.8) | 2 (9.5) | 18 (85.7) | 0 (0.0) | 7 (33.3) | 14 (66.7) | 1 (4.8) | 3 (14.3) | 17 (81.0) | 2 (9.5) | 7 (33.3) | 12 (57.1) |
Duke’s classification | P = 0.00038 | P = 0.0037 | P = 0.00124 | NS | P = 0.015936 | |||||||||||
A | 38 | 7 (18.4) | 15 (39.5) | 16 (42.1) | 3 (7.9) | 15 (39.5) | 20 (52.6) | 11 (28.9) | 14 (36.8) | 13 (34.2) | 5 (13.2) | 12 (31.6) | 21 (55.3) | 13 (34.2) | 14 (36.8) | 11 (28.9) |
B | 29 | 1 (3.4) | 4 (13.8) | 24 (82.8) | 0 (0.0) | 6 (20.7) | 23 (79.3) | 1 (3.4) | 2 (6.9) | 26 (89.7) | 1 (3.4) | 5 (17.2) | 23 (79.3) | 3 (10.3) | 2 (6.9) | 24 (82.8) |
C1 | 17 | 1 (5.9) | 2 (11.8) | 14 (82.4) | 1 (5.9) | 3 (17.6) | 13 (76.5) | 0 (0.0) | 5 (29.4) | 12 (70.6) | 0 (0.0) | 2 (11.8) | 15 (88.2) | 2 (11.8) | 8 (47.1) | 7 (41.2) |
C2 | 8 | 0 (0.0) | 1 (12.5) | 7 (87.5) | 0 (0.0) | 1 (12.5) | 7 (87.5) | 1 (12.5) | 2 (25.0) | 5 (62.5) | 0 (0.0) | 4 (50.0) | 4 (50.0) | 1 (12.5) | 3 (37.5) | 4 (50.0) |
D | 4 | 0 (0.0) | 2 (50.0) | 2 (50.0) | 0 (0.0) | 0 (0.0) | 4 (100.0) | 0 (0.0) | 2 (50.0) | 2 (50.0) | 1 (25.0) | 0 (0.0) | 3 (75.0) | 1 (25.0) | 0 (0.0) | 3 (75.0) |
- Citation: Nakayama T, Hatachi G, Wen CY, Yoshizaki A, Yamazumi K, Niino D, Sekine I. Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors. World J Gastroenterol 2005; 11(7): 964-969
- URL: https://www.wjgnet.com/1007-9327/full/v11/i7/964.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i7.964