Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors

Table 1 Histological differentiation, invasion and Tie-1, 2 and Ang-1, 2, 4 expressions in human colorectal adenocarcinoma (n = 96), n (%).

	n	Tie-1			Tie-2			Ang-1			Ang-2			Ang-4
		-	+	++	-	+	++	-	+	++	-	+	++	-	+	++
Adenoma	11	7 (63.6)	3 (27.3)	1 (9.1)	6 (54.5)	3 (27.3)	2 (18.1)	7 (63.6)	3 (27.3)	1 (9.1)	7 (63.6)	3 (27.3)	1 (9.1)	8 (72.2)	3 (27.3)	0 (0.0)
Total carcinoma	96	9 (9.4)	24 (25.0)	63 (65.6)	4 (4.2)	25 (26.0)	67 (69.8)	13 (13.5)	25 (26.0)	58 (60.4)	7 (7.3)	23 (24.0)	66 (69.0)	20 (20.8)	27 (28.1)	49 (51.0)
Histological differentiation		P = 0.000123			P = 0.002209			P = 0.000161			NS			P = 0.008193
Ca in adenoma	18	3 (16.7)	8 (44.4)	7 (38.9)	1 (5.6)	7 (38.9)	10 (55.6)	6 (33.3)	7 (38.9)	5 (27.8)	3 (16.7)	4 (22.2)	11 (61.1)	6 (33.3)	7 (38.9)	5 (27.8)
Well	29	5 (17.2)	7 (24.1)	17 (58.6)	2 (6.9)	12 (41.4)	15 (51.7)	4 (13.8)	7 (24.1)	18 (62.1)	2 (6.9)	7 (24.1)	20 (69.0)	7 (24.1)	7 (24.1)	15 (51.7)
Moderate	38	0 (0.0)	7 (18.4)	31 (81.6)	0 (0.0)	5 (13.2)	33 (86.8)	2 (5.3)	8 (21.1)	28 (73.7)	1 (2.6)	8 (21.1)	29 (76.3)	3 (7.9)	11 (28.9)	24 (63.2)
Poor	6	0 (0.0)	0 (0.0)	6 (100.0)	0 (0.0)	1 (16.7)	5 (83.3)	0 (0.0)	0 (0.0)	6 (100.0)	0 (0.0)	2 (33.3)	4 (66.7)	1(16.7)	1 (16.7)	4 (66.7)
Mucinous	5	1 (20.0)	2 (40.0)	2 (40.0)	1 (20.0)	0 (0.0)	4 (80.0)	1 (20.0)	3 (60.0)	1 (20.0)	1 (20.0)	2 (40.0)	2 (40.0)	3 (60.0)	1 (20.0)	1 (20.0)
Depth of tumor invasion		P = 0.000473			P = 0.006137			P = 0.000747			P = 0.0097			P = 0.000949
Tis	20	4 (20.0)	9 (45.0)	7 (35.0)	2 (10.0)	7 (35.0)	11 (55.0)	7 (35.0)	8 (40.0)	5 (25.0)	3 (15.0)	6 (30.0)	11 (55.0)	7 (35.0)	8 (40.0)	5 (25.0)
T1	8	3 (37.5)	3 (37.5)	2 (25.0)	1 (12.5)	5 (62.5)	2 (25.0)	4 (50.0)	3 (37.5)	1 (12.5)	2 (25.0)	3 (37.5)	3 (37.5)	6 (75.0)	1 (12.5)	1 (12.5)
T2	10	0 (0.0)	2 (20.0)	8 (80.0)	0 (0.0)	2 (20.0)	8 (80.0)	0 (0.0)	2 (20.0)	8 (80.0)	0 (0.0)	4 (40.0)	6 (60.0)	1 (10.0)	4 (40.0)	5 (50.0)
T3	37	1 (2.7)	6 (16.2)	30 (81.1)	0 (0.0)	9 (24.3)	28 (75.7)	2 (5.4)	5 (13.5)	30 (81.1)	1 (2.7)	7 (18.9)	29 (78.4)	4 (10.8)	7 (18.9)	26 (70.3)
T4	21	1 (4.8)	4 (19.0)	16 (76.2)	1 (4.8)	2 (9.5)	18 (85.7)	0 (0.0)	7 (33.3)	14 (66.7)	1 (4.8)	3 (14.3)	17 (81.0)	2 (9.5)	7 (33.3)	12 (57.1)
Duke’s classification		P = 0.00038			P = 0.0037			P = 0.00124			NS			P = 0.015936
A	38	7 (18.4)	15 (39.5)	16 (42.1)	3 (7.9)	15 (39.5)	20 (52.6)	11 (28.9)	14 (36.8)	13 (34.2)	5 (13.2)	12 (31.6)	21 (55.3)	13 (34.2)	14 (36.8)	11 (28.9)
B	29	1 (3.4)	4 (13.8)	24 (82.8)	0 (0.0)	6 (20.7)	23 (79.3)	1 (3.4)	2 (6.9)	26 (89.7)	1 (3.4)	5 (17.2)	23 (79.3)	3 (10.3)	2 (6.9)	24 (82.8)
C1	17	1 (5.9)	2 (11.8)	14 (82.4)	1 (5.9)	3 (17.6)	13 (76.5)	0 (0.0)	5 (29.4)	12 (70.6)	0 (0.0)	2 (11.8)	15 (88.2)	2 (11.8)	8 (47.1)	7 (41.2)
C2	8	0 (0.0)	1 (12.5)	7 (87.5)	0 (0.0)	1 (12.5)	7 (87.5)	1 (12.5)	2 (25.0)	5 (62.5)	0 (0.0)	4 (50.0)	4 (50.0)	1 (12.5)	3 (37.5)	4 (50.0)
D	4	0 (0.0)	2 (50.0)	2 (50.0)	0 (0.0)	0 (0.0)	4 (100.0)	0 (0.0)	2 (50.0)	2 (50.0)	1 (25.0)	0 (0.0)	3 (75.0)	1 (25.0)	0 (0.0)	3 (75.0)

NS; not significant.