Effect of rhubarb on contractile response of gallbladder smooth muscle strips isolated from guinea pigs

Table 3 Effect of rhubarb on the contractile frequency (waves/min) of isolated guinea pig gallbladder muscle strip after pretreatment with antagonists (mean±SE).

Frequency (w/min)	Rhubarb (g/L)
	0	0.05	0.15	5	15	50	100
Rhubarb	4.1±0.5	4.0±0.4	4.1±0.5	4.4±0.4	5.0±0.3	6.3±0.5c	6.1±0.4c
Phe+rhu	4.2±0.5	4.5±0.5	4.6±0.6	4.6±0.5	4.8±0.6	5.5±0.6	6.0±0.5c
Hex+rhu	3.7±0.3	3.8±0.4	3.8±0.4	4.1±0.5	4.9±0.6	5.3±0.7c	5.5±0.5c
Atr+rhu	3.5±0.4	3.4±0.4	3.5±0.4	3.7±0.4	4.0±0.4	4.8±0.5c	5.0±0.5c
Iso+rhu	4.1±0.4	4.1±0.4	4.1±0.4	4.2±0.4	4.5±0.4	5.0±0.5	4.9±0.4

^aP<0.05,

^cP<0.005 vs control (the gallbladder spontaneous contraction frequency under 1-g initial load when rhubarb was 0 g/L) n = 12.