Interleukin-10 -1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China

Table 2 Association analysis of the IL-10 –1082 promoter polymorphism with the risk of ESCC and GCA development.

	A/A	A/G+G/G	aOR (95%CI)3
Overall
Normal	267 (60.3)	176 (39.7)
ESCC	117 (57.6)	86 (42.4)	0.92 (0.76–1.11)
GCA	93 (61.2)	59 (38.8)	0.95 (0.61–1.46)
Nonsmoker1
Normal	181 (62.4)	109 (37.6)
ESCC	52 (61.2)	33 (38.8)	0.89 (0.67–1.18)
GCA	26 (59.1)	18 (40.9)	0.79 (0.39–1.63)
Smoker
Normal	80 (55.6)	64 (44.4)
ESCC	61 (57.5)	45 (42.5)	1.01 (0.77–1.33)
GCA	54 (61.4)	34 (38.6)	1.11 (0.61–2.02)
Negative family history2
Normal	168 (60.2)	111 (39.8)
ESCC	48 (56.5)	37 (43.5)	0.92 (0.70-1.20)
GCA	30 (63.8)	17 (36.2)	1.10 (0.54-2.22)
Positive family history
Normal	99 (60.4)	65 (39.6)
ESCC	56 (60.2)	37 (39.8)	0.96 (0.71–1.29)
GCA	40 (54.0)	34 (46.0)	0.71 (0.37–1.36)

ESCC: esophageal squamous cell carcinoma. GCA: gastric cardiac adenocarcinoma. ^1,2information of smoking status and family history was available from a subset of subjects;

³The age and sex adjusted odds ratio of the A/G+G/G genotype against the A/A genotype.