Interleukin-10 -1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China

Table 1 Selected characteristics of ESCC, GCA patients and healthy individuals.

Groups	Control, n (%)	ESCC, n (%)	Pa	GCA, n (%)	P1
Sex
Male	269 (60.7)	135 (66.5)	0.16	102 (67.1)	0.16
Female	174 (39.3)	68 (33.5)	50 (32.9)
Mean age, in years (SD)	57.1 (10.27)	59.2 (9.58)	0.062	60.7 (8.07)	0.062
Smoking status3
Ex- or current smoker	144 (33.2)	106 (55.5)	<0.0015	88 (66.7)	<0.0015
Non-smoker	290 (66.8)	85 (44.5)		44 (33.3)
Family history of UGIC4
Positive	164 (37.0)	93 (52.2)	<0.001f	74 (61.2)	<0.0016
Negative	279 (63.0)	85 (47.8)		47 (38.8)
IL-10 -G1082A SNP genotype
A/A	267 (60.3)	117 (57.6)	0.78	93 (61.2)	0.88
A/G	164 (37.0)	81 (39.9)		56 (36.8)
G/G	12 (2.7)	5 (2.5)		30 (2.0)
IL-10 -G1082A SNP allelotype
A	698 (78.8)	315 (77.6)	0.63	242 (79.6)	0.76
G	188 (21.2)	91 (22.4)		62 (20.4)

ESCC: esophageal squamous cell carcinoma, GCA: gastric cardiac adenocarcinoma, UGIC: upper gastrointestinal cancer. ¹P value for χ² test;

²P value for t test; ^3,4information of smoking status and family history was available from a subset of subjects;

⁵smoking significantly increased the risk to the ESCC development (the age and sex adjusted OR = 1.42, 95% CI = 1.11–1.81); and GCA development (the age and sex adjusted OR = 2.64, 95% CI = 1.46–4.76);

⁶positive family history of UGIC significantly increased the risk to develop ESCC (the age and sex adjusted OR = 1.44, 95%CI = 1.18-1.75) and GCA (the age and sex adjusted OR = 3.10, 95%CI = 1.94–4.97).