Loss of heterozygosity: An independent prognostic factor of colorectal cancer

Table 3 Comparison between clinico-pathological features of MSI-H and MSS in colorectal cancer, n (%).

Features	Total	MSI-H	MSS	P
Number of cases (%)	207	15 (7.25)	192 (92.7)
Age (yr)	66.2±12.4	69.7±14.8	65.9±12.2	0.2481
Gender(male/female)	139/68	8/7	131/61	0.3692
Location of tumor
Right colon	37 (17.9)	7 (46.7)	30 (15.6)	0.0053
Left colon	85 (41.1)	2 (13.3)	83 (43.2)
Rectum	85 (41.1)	6 (40.0)	79 (41.2)
TNM stage
I	25 (14.2)	1 (6.7)	24 (12.5)	0.7804
II	73 (36.8)	6 (40.0)	67 (34.9)
III	68 (31.6)	6 (40.0)	62 (32.3)
IV	41 (17.4)	2 (13.3)	39 (20.3)
Invasive pattern
Expanding	52 (25.1)	4 (26.7)	48 (25.0)	1.02
Infiltrative	155 (74.9)	11 (73.3)	144 (75.0)
Grade of differentiation
Well	5 (2.4)	0	5 (2.6)	<0.0013
Moderate	182 (87.9)	9 (60.0)	173 (90.1)
Poor	20 (9.7)	6 (40.0)	14 (7.3)
Lymphovascular invasion
Yes	48 (23.2)	1 (6.7)	47 (24.5)	0.2092
No	159 (76.8)	14 (93.3)	145 (75.5)
Mucin component
Yes	29 (14.0)	7 (46.7)	22 (11.5)	0.0012
No	178 (86.0)	8 (53.3)	170 (88.5)

¹Student t test,

²Fisher exact test,

³Pearson χ² test,

⁴χ² test with linear-by-linear association.