Loss of heterozygosity: An independent prognostic factor of colorectal cancer

Table 2 Comparison between clinico-pathological features of loss of heterozygosity-high and loss of heterozygosity-low in colorectal cancer, n (%).

Features	Total	LOH-high	LOH-low	P
Number of cases	207	93 (44.9)	114 (55.1)
Age (yr)	66.2±12.4	67.2±12.4	65.4±12.3	0.2921
Gender (male/female)	139/68	61/32	78/36	0.7782
Location of tumor
Right colon	37 (17.9)	16 (17.2)	21 (18.4)	0.5443
Left colon	85 (41.1)	42 (45.2)	43 (37.7)
Rectum	85 (41.1)	35 (37.6)	50 (43.9)
TNM stage
I	25 (12.1)	7 (7.5)	18 (15.8)	<0.0014
II	73 (35.3)	22 (23.7)	51 (44.7)
III	68 (32.9)	37 (39.8)	31 (27.2)
IV	41 (19.8)	27 (29.0)	14 (12.3)
Invasive pattern
Expanding	52 (25.1)	20 (21.5)	32 (28.1)	0.2862
Infiltrative	155 (74.9)	73 (78.5)	82 (71.9)
Grade
Well-differentiated	5 (2.4)	2 (2.2)	3 (2.6)	0.2633
Moderate differentiated	182 (87.9)	81 (87.0)	101 (88.6)
Poorly differentiated	20 (9.7)	10 (10.8)	10 (8.8)
Lymphovascular invasion
Yes	48 (23.2)	27 (56.3)	21 (43.7)	0.1022
No	159 (76.8)	66 (41.5)	93 (58.5)
Mucin production
Yes	29 (14.0)	9 (9.7)	20 (17.5)	0.1552
No	178 (86.0)	84 (90.3)	94 (82.5)

¹Student t test,

²Fisher exact test,

³Pearson χ² test,

⁴χ² test with linear-by-linear association.