Toxicity of novel anti-hepatitis drug bicyclol: A preclinical study

Table 6 Blood biochemical parameters of female and male beagle dogs 6 mo after bicyclol treatment (mean±SD).

Parameter	Control	Bicyclol (mg/kg)
		25	75	225
Female
Glu mmol/L	4.94±0.83	6.06±0.38	5.60±0.08	6.36±0.62
T-CHO mmol/L	2.56±1.08	2.82±0.60	2.97±1.02	3.43±1.39
TP g/L	71.3±0.2	74.3±4.2a	73.5±3.3	76.1±6.2
ALB g/L	37.0±0.9	39.9±1.7	41.0±3.7	44.0±4.1
Crea mmol/L	119±28	138±10	145±42	143±27
BUN mmol/L	4.25±0.05	3.51±0.24	4.22±0.29	3.60±0.78
T-BIL mmol/L	2.80±1.70	4.00±2.26	3.60±0.57	1.20±0.40
SGPT 10 U/L	26.2±1.3	28.3±15.0	12.8±8.9	25.2±8.1
SGOT 10 U/L	61.8±14.9	41.3±14.6	45.1±8.0	45.8±23.8
ALP 10 U/L	2.65±1.51	1.95±0.39	2.55±0.38	3.14±1.12
Male
Glu mmol/L	5.79±0.29	5.19±0.44	5.58±0.88	4.65
T-CHO mmol/L	2.37±0.35	2.82±0.60	2.39±0.06	2.65
TP g/L	74.2±5.2	71.6±9.8	79.1±12.2	70.6
ALB g/L	34.9±1.6	38.7±1.5	42.4±7.5	33.4
Crea mmol/L	136±10	136±9.8	165±39	105
BUN mmol/L	3.43±0.63	3.94±0.58	2.95±0.34	3.2
T-BIL mmol/L	4.40±0.57	4.00±0.00	3.20±0.80	2.8
SGPT 10 U/L	34.6±9.9	23.1±6.9	25.7±9.9	36
SGOT 10 U/L	57.9±11.6	37.9±5.8	54.5±7.3	53.3
ALP 10 U/L	2.51±0.46	5.41±4.59	2.23±1.16	1.94

^aP<0.05 vs control group.