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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Feb 7, 2005; 11(5): 665-671
Published online Feb 7, 2005. doi: 10.3748/wjg.v11.i5.665
Published online Feb 7, 2005. doi: 10.3748/wjg.v11.i5.665
Table 5 Blood test of female and male beagle dogs before and after treatment with 225 mg/kg bicyclol (mean±SD).
| Parameter | Before treatment | After treatment (mo) | ||||
| 1.5 | 3 | 4.5 | 6 | 7 (n = 1) | ||
| Female (n = 4) | ||||||
| RBC ×1012/L | 8.9±2.1 | 9.0±2.5 | 8.1±1.6 | 10.0±0.8 | 9.0±2.3 | 8.8 |
| Hb g/L | 141±9 | 151±9 | 141±6 | 153±12 | 165±13a | 155 |
| RET (%) | 1.0±0.2 | 0.6±0.1 | 0.8±0.2 | 0.7±0.1 | 0.8±0.2 | 0.8 |
| PLT ×109/L | 195±55 | 230±37 | 217±29 | 237±15 | 313±25a | 368 |
| WBC ×109/L | 10.6±2.2 | 10.2±0.7 | 12.2±3.2 | 10.5±2.4 | 12.2±3.0 | 10.9 |
| Lymphocyte (%) | 51±6 | 52±8 | 60±11 | 59±11 | 59±10 | 63 |
| Polymorphonuclear | ||||||
| Leukocyte (%) | 44±6 | 43±8 | 37±6 | 39±9 | 36±8 | 31 |
| Monocyt (%) | 3.8±1.3 | 4.5±0.6 | 3.0±1.2 | 2.0±2.0 | 5.3±3.1 | 6 |
| Male (n = 2) | ||||||
| RBC ×1012/L | 8.9±0.3 | 10.4±0.0a | 9.9±1.6 | 7.4 | 7.9 | 7.5 |
| Hb g/L | 140±14 | 142±9 | 140±7 | 155 | 160 | 145 |
| RET (%) | 1.1±0.1 | 0.9±0.2 | 1.0±0.4 | 0.9 | 0.8 | 0.6 |
| PLT ×109/L | 215±7 | 290±0a | 138±23a | 210 | 260 | 248 |
| WBC ×109/L | 9.3±0.6 | 9.5±0.7 | 11.2±1.9 | 6.9 | 12.8 | 14.4 |
| Lymphocyte (%) | 55±4 | 51±11 | 52±6 | 48 | 55 | 67 |
| Polymorphonuclear | ||||||
| Leukocyte (%) | 41±3 | 46±11 | 46±6 | 48 | 40 | 26 |
| Monocyt (%) | 3.5±0.7 | 3.0±0.0 | 4.0±1.4 | 4 | 5 | 7 |
- Citation: Liu GT, Li Y, Wei HL, Lu H, Zhang H, Gao YG, Wang LZ. Toxicity of novel anti-hepatitis drug bicyclol: A preclinical study. World J Gastroenterol 2005; 11(5): 665-671
- URL: https://www.wjgnet.com/1007-9327/full/v11/i5/665.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i5.665