Toxicity of novel anti-hepatitis drug bicyclol: A preclinical study

Table 2 Effect of bicyclol on organ weight in rats (n = 10, mean±SD).

Organ weightmg/100g BW	Sex	Control	Bicyclol (mg/kg)
			150	300	600
Heart	M	308±38	300±42	310±74	360±70
Liver		2960±310	3120±610	3200±810	3300±700
Lung		570±120	620±280	580±160	700±180
Kidney		670±70	660±120	700±180	580±270
Spleen		160±30	170±40	170±43	140±45
Thymus		60±20	60±20	60±17	45±18
Pituitary		3±4	2±1	2±1	2±1
Adrenal		20±10	24±30	14±3	16±4
Prostate		110±30	120±30	109±29	110±40
Seminal		250±80	240±80	250±55	260±66
Testis		1150±160	1120±180	1040±301	1130±296
Heart	F	350±40	360±38	380±40	370±41
Liver		3200±330	3300±220	3300±210	3300±290
Lung		970±320	890±280	700±80	680±291
Kidney		810±110	820±100	810±140	770±130
Spleen		220±44	210±36	240±34	320±54b
Thymus		102±36	67±23b	53±24b	120±88
Pituitary		5±2	3±1	5±2	12±15
Adrenal		29±4	26±4	29±3	51±8
Uterus		173±50	147±48	163±31	158±57
Ovary		39±19	34±24	37±3	47±25

^bP<0.01 vs control group.