Toxicity of novel anti-hepatitis drug bicyclol: A preclinical study

Table 1 Effect of bicyclol on blood picture and biochemical markers in rats (mean±SD).

Group (mg/kg)		Blood picture					Classification of leukocytes,RET and PT
		Sex	RBC(104/mm3)	WBC(/mm3)	Hb (g/dL)	HCT (%)	Leukocytes (%)			RET (%)	Platelet (1×109/L)
							Neutrophil	Lymphocyte	Reticulocyte
Control		M	713.8±95.8	14400±3969	17.3±1.4	37.5±5.2	39.3±7.05	58.6±4.32	4.5±2.06	1.55±0.99	900.75±136.07
Bicyclol	150		753.7±55.0	14102±3531	17.1±0.8	38.8±3.6	39.0±8.12	58.6±6.97	2.0±0.89	0.86±0.26	837.60±155.62
	300		609.1±109	15850±5813	15.4±5.3	31.7±11	29.6±9.22	68.4±9.07	2.0±0.63	1.14±0.91	905.60±106.10
	600		593.2±86.8a	11477±1919	14.7±1.5a	29.7±3.8	-	-	-	-	-
Control		F	681.9±104	13230±3671	16.8±1.99	35.1±5.0	29.4±13.47	67.8±13.9	2.4±2.5	1.04±0.62	763.20±144.50
Bicyclol	150		620.1±104	13220±2721	15.7±1.25	31.3±3.7	33.4±10.07	65.4±11.7	1.0±0.9	0.74±0.37	715.60±76.20
	300		626.9±70	12656±1461	15.3±1.52	34.6±3.9	45.0±8.7	53.4±8.7	1.6±1.6	0.92±0.55	831.6±82.20
	600		622.9±80	10777±4355	14.7±1.51	34.1±4.4	42.0±15.6	54.4±14.6	3.6±2.9	0.70±0.49	562.4±273.30

^aP<0.05 vs control group.