In vitro resistance to interferon of hepatitis B virus with precore mutation

Table 3 HBsAg and HBV DNA secreted into cell culture medium with or without IFN (mean±SD).

Recombinants	HBsAg (A450)		HBV DNA (realtime PCR, log10)
	Without IFN	With IFN	Without IFN	With IFN
Puc18-HBV1.2-WT	2.63±0.1c	1.96±0.07c	5.02±0.06ac	4.86±0.07c
Puc18-HBV1.2-A1896	1.43±0.05	1.46±0.07	4.43±0.09ac	5.53±0.07c
Puc18-HBV1.2-A1899	1.97±0.15	1.96±0.12	4.80±0.05	4.90±0.06
Puc18-HBV1.2-AA	2.6±0.05	2.5±0.06	4.06±0.07ac	4.46±0.05c

n = 3,

^aP<0.05 (WT in comparison with MT without IFN),

^cP<0.05 (without IFN in comparison with with IFN). WT: wild type, MT: mutated type.