Elevated plasma von Willebrand factor levels in patients with active ulcerative colitis reflect endothelial perturbation due to systemic inflammation

Table 3 Laboratory parameters at baseline and after 12 wk of therapy in active UC patients who completed the study (n = 32) (mean±SD)

	Weeks of follow-up	Responders	Non-responders
	Paired samples t test	n = 22	n = 10
ESR (mm/h)	Baseline	43±24	34±13
	12th week	32±18	27±12
	P	0.055	0.206
CRP (mg/L)	Baseline	27.21±42.13	22.24±41.2
	12th week	11.11±25.57	11.42±13.29
	P	0.106	0.460
Fibrinogen (g/L)	Baseline	4.9±1.13	4.98±1.48
	12th week	4.05±0.68	4.55±0.82
	P	0.001	0.372
vWF (%)	Baseline	153.91±69.53	129.3±50.35
	12th week	111.14±30.65	105.4±32.87
	P	0.005	0.153
F1+2 (nmol/L)	Baseline	3.73±5.73	4.21±7.26
	12th week	1.23±1.12	0.71±0.26
	P	0.043	0.186
D-dimers (μg/L)	Baseline	1 202±1 522	302±329
	12th week	251±288	683±1 286
	P	0.005	0.381
TAT (μg/L)	Baseline	4.39±4.6	13.43±26.94
	12th week	5.41±13.1	1.97±1.57
	P	0.733	0.211

vWF: von Willebrand factor; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; F1+2: prothrombin fragments 1+2; TAT: thrombin–antithrombin complexes.