Elevated plasma von Willebrand factor levels in patients with active ulcerative colitis reflect endothelial perturbation due to systemic inflammation

Table 2 Acute phase reactants and coagulation factors in patients with ulcerative colitis and healthy controls (mean±SD)

	Active UC (n = 34)	Inactive UC (n = 12)	Healthy controls (n = 52)
vWF (%)	143.38±63.73 (49-278)	98.92±43.6a (25-188)	100.75±29.65b (51–160)
ESR (mm/h)	40±21 (10-97)	16±12a (4-40)
CRP (mg/L)	24.7±40.2 (3.1-175.5)	4.1±1.7a (3.1-7.3)
Fibrinogen (g/L)	4.86±1.21 (2.93-7.3)	3.48±1.14a (1.25-5.61)
D-dimers (μg/L)	873±1 308 (32-3 993)	608±1 149 (19-4 038)
F1+2 (nmol/L)	3.71±6.09 (0.21–22.53)	3.72±6.41 (0.28-21.52)
TAT (μg/L)	6.91±15.18 (0.09–85.9)	3.99±4.2 (0.85-13.2)

vWF: von Willebrand factor; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; F1+2: prothrombin fragments 1+2; TAT: thrombin–antithrombin complexes.

^aP<0.05 active UC vs inactive UC.

^bP<0.001 active UC vs HC.