Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus

Table 1 Differential expression of immunity-related genes in PBMCs of HBV identical twin patients

UniGene ID	Gene name	Known function(s)	Fold change
Hs.244613	Signal transducer and activator of transcription 5b (STAT 5b)	Signal transducer of IL-2, IL-4, CSF1, and different growth hormones. I mportant for TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression	–4.2
Hs.239138	Pre-B-cell colony-enhancing factor (PBEF)	A cytokine that increases the expression of IL-6 and IL-8 in fetal membrane and may be important in both normal spontaneous labor and infection-induced preterm labor	2.2
Hs.158315	Interleukin 18 receptor accessory protein (IL-18RAP)	An accessory subunit of the heterodimeric receptor for IL-18 enhances the IL-18 binding a ligand binding subunit of IL-18 receptor. The coexpression of IL-18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL-18	3.0
Hs.76090	Tumor necrosis factor-alpha-induced protein 1 (endothelial) (TNF-αIP1)	Unknown	2.3
Hs.225948	Chemokine (C-C motif) ligand 27 (CCL27)	Cytokine that plays a role in mediatinghoming of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of murine protein indicate that these protein-receptor interactions have a pivotal role in T-cell-mediated skin inflammation	-2.5
Hs.301921	C-C chemokine receptor type 1 (C-C CKR-1)	Cytokine receptor important for host protection from inflammatory response and susceptibility to virus and parasite	-2.7
Hs.57735	Scavenger receptor class F, member 1 (SCARF1)	Scavenger receptor that has roles in the binding and degradation of acetylated low density lipoprotein and may be involved in atherosclerosis	-2.2
Hs.4930	Low density lipoprotein receptor-related protein 4 (LRP4)	A membrane protein which may be involved in calcium ion binding	-2.8

¹Fold changes between the HBV immune twin pair. Positive number indicates upregulation, whereas negative number denotes downregulation.