Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett’s esophagus

Figure 1 Pathological findings in the esophagus of rats with esophagojejunostomy. (A) Development of intestinal metaplasia in the area of anastomosis contiguous to the jejunal epithelium. Characteristic jejunal epithelial villi (white arrow) contrast with blunt villi of metaplastic areas (black arrow). The gray arrow shows the site of anastomosis (H&E staining, ×12.5); (B) A higher magnification of (A) shows the metaplastic epithelium in detail, with incomplete development of villi and crypts lined by absorptive cells with brush borders and goblet cells (H&E, ×100); (C) Intestinal metaplasia developed distant from the anastomosis, consisting of isolated goblet cells immersed within squamous epithelium (H&E, ×100); (D) Formation of mucus glands in squamous epithelium; (E) Development of mucinous adenocarcinoma from metaplasia in continuity, infiltrating the esophageal wall in depth. The site of anastomosis is shown by the gray arrow (H&E, ×12.5).