Gene expression profiling of gastric cancer by microarray combined with laser capture microdissection

Table 1 Up-regulated genes noted in gastric cancer

Biosynthesis
Argininosuccinate synthetase [BC009243], hydroxymethylbilane synthase [BC000520], hypothetical protein CL640 [BC008804], methylenetetrahydrofolate dehydrogenase (NADP+-dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase [BC001014]
Cell adhesion
Collagen, type XVIII, alpha 1 [AF01808], mesothelin [U40434], CD9 antigen (p24) (X60111), collagen, type VI, alpha 3 [X52022], thrombospondin 2 [L12350], immunoglobulin superfamily containing leucine-rich repeat [AB003184]
Cell death
Nerve growth factor receptor (TNFR superfamily, member 16) [M14764], phosphoprotein enriched in astrocytes 15 [AF153274], programmed cell death 5 [AF014955]
Cell growth and/or maintenance
Cell division cycle 25B [S78187], cyclin D2 [D13639], hippocalcin [BC001777], anillin, actin binding protein (scraps homolog, Drosophila) [AF273437], afamin [L32140], chromosome 14 open reading frame 58 [AK000378], C1q and tumor necrosis factor related protein 1 [AF32984], low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [D86407], enhancer of rudimentary homolog (Drosophila) [U66871], tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) [D11139], insulin receptor substrate 2 [AF073310], low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [D50678], thyroid hormone receptor interactor 10 [AJ000414], collagen, type I, alpha 1 [Z74615], ATPase, Na+/K+ transporting, beta 3 polypeptide [AF005896], T-LAK cell-originated protein kinase [AB027249], platelet-derived growth factor receptor, beta polypeptide [J03278], nucleolar protein 1 120 ku [BC000656], keratin 7 [BC002700], oncostatin M receptor [BC010943], tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) [BC000866], insulin-like growth factor 2 (somatomedin A) [S77035], karyopherin (importin) beta 1 [L38951], nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) [X07315], nucleolar protein 1 120ku [X55504], thymosin beta-10 [S54005]
Cell motility
Hyaluronan-mediated motility receptor (RHAMM) [AF03286], sorcin [M32886], troponin T1, skeletal, slow [BC010963]
Cell-cell signaling
Ephrin-A2 [U92896], midkine (neurite growth-promoting factor 2) [X55110], prostaglandin I2 (prostacyclin) receptor (IP) [D25418]
Immune response
Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) [X14831], Human 1-8D gene from interferon-inducible gene family [X57351], GTP binding protein over-expressed in skeletal muscle [U10550], indoleamine-pyrrole 2,3 dioxygenase [M34455], interferon induced transmembrane protein 1 (9-27) [J04164]
Macromolecule metabolism
Cathepsin L2 [AB001928], PAK2 [AF09213], ribosomal protein, large P2 [M17887], hypothetical protein FLJ22761 [AK026414], KIAA0205 [D86960], proteasome (prosome, macropain) subunit, alpha type, 1 [D00759], protein tyrosine phosphatase type IVA, member 1 [U48296], peptidylprolyl isomerase (cyclophilin)-like 1 [BC003048], ribosomal protein L14 [BC009294], pyruvate kinase, muscle [BC007952], proteasome (prosome, macropain) subunit, alpha type, 7 [BC001895], isocitrate dehydrogenase 3 (NAD+) alpha [U07681], transglutaminase 4 (prostate) [U31905]
Organogenesis
Secreted protein, acidic, cysteine-rich (osteonectin) [M25743], caudal type homeo box transcription factor 2(CDX2) [AJ278434], transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) [M36711]
Regulation of metabolism
Homeo box B7 [BC015345], B-cell receptor-associated protein 37 [AF126021], Mediterranean fever [AJ003147], homeo box B7 [M16937], homeo box D4 [X17360], TIP49 [AB012122], sin3-associated polypeptide, 18 ku [AF153608]
Response to stress
Complement component 2 [X04481], complement component 3 [K02765], inhibin, beta A (activin A, activin AB alpha polypeptide) [X57579], serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 [K02212], serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) [D83174], meiotic recombination (S. cerevisiae) 11 homolog A [AF073362], RecQ protein-like 4 [BC013277]
Signal transduction
Secreted frizzled-related protein 4 [AF026692], lymphocyte antigen 6 complex, locus E(RIG-E) [Z68179], dimethylarginine dimethylaminohydrolase 2 [BC001435]
Unclassified
Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [BI826471], apolipoprotein C-I [AV709433], argininosuccinate synthetase [BF305206], ATPase, Ca++ transporting, plasma membrane 4 [AI885833], ATPase, Na+/K+ transporting, beta 3 polypeptide [AU151263], B-cell associated protein [BG771222], BTG family, member 2 [BG750101], cadherin 3, type 1, P-cadherin (placental) [NM001793], calcium modulating ligand [AW474551], carbonyl reductase 3 [AI658832], cathepsin Z [AI913006], CDC-like kinase 2 [BG286233], cell division cycle 25B [BF976307], CGI-01 protein [AK027886], chloride intracellular channel 1 [AA291390], claudin 4 [BI760179], claudin 7 [AI279608], collagen, type I, alpha 1 [AW577407], collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia) [NM000493], core-binding factor, beta subunit [NM001755], D123 gene product [BE792735], deoxythymidylate kinase (thymidylate kinase) [BF312526], diubiquitin [AW270961], DKFZP566C134 protein [BG621382], E2F transcription factor 3 [AU153511], epithelial protein lost in neoplasm alpha [AAF23756], exostoses (multiple) 1 [BF057267], FK506-binding protein 4 (59 ku) [NM002014], follistatin-like 3 (secreted glycoprotein) [NM005860], forkhead box M1 [AL525810], glutamine-fructose-6-phosphate transaminase 2 [AK001242], GTP-binding protein over-expressed in skeletal muscle [AW297828], guanylate cyclase 2C (heat stable enterotoxin receptor) [NM004963], heme oxygenase (decycling) 1 [BI596354], HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2 [BG167159], Homo sapiens cDNA FLJ11796 fis, clone HEMBA1006158, highly similar to Homo sapiens transcription factor forkhead-like 7 [FKHL7] gene [BI914918], homo sapiens mRNA for short form of beta II spectrin, partial [AA131993], human cDNA: FLJ22528 fis, clone HRC12825 [AK026181], human cDNA: FLJ22998 fis, clone KAT11985, highly similar to AB000712 Human hCPE-R mRNA for CPE-receptor [AK026651], human chromosome 20 clone h119, complete sequence [AF312913], human claudin 3 [CLDN3] gene, [AF007189], regenerating islet-derived family, member 4 [AF254415], human genomic DNA, chromosome 22q11.2, clone KB1125A3 [AP000350], likely ortholog of mouse membrane bound C2 domain containing protein [AB018290], KIAA0930 protein [AB02314], hypothetical protein LOC90499 [AL137712], fuse-binding protein-interacting repressor [AF190744], Thy-1 cell surface antigen [M11749], biglycan [BC002416], CK2 interacting protein 1; HQ0024c protein [BC010149], hypothetical protein FLJ12436 [BC011993], tissue inhibitor of metalloprotease 1 (erythroid potentiating activity, collagenase inhibitor) [BC000866], hypothetical protein FLJ20277 [M11749], hypothetical protein FLJ22393 [H45848],hypothetical protein PRO1489 [AI536671], interferon induced transmembrane protein 1 (9-27) [BG506643], interferon induced transmembrane protein 3 (1-8U) [BE886918], interleukin 13 [NM002188], interleukin 8 [BG777366], JM4 protein [BI818455], keratin 7 [BI094014], keratin 7 [AA307373], KIAA0747 protein [BG744628], low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [BF110337], lymphocyte antigen 6 complex, locus E [BM101706], matrix metalloproteinase 7 (matrilysin, uterine) [NM002423], membrane protein of cholingeric synaptic vesicles [BG760616], mesothelin [AI813749], midkine (neurite growth-promoting factor) [AI784469], msh (Drosophila) homeo box homolog 1 [AI912103], MyoD family inhibitor [BG675569], neural precursor cell expressed, developmentally down-regulated 5 [AU131176], neuromedin U [BG661038], NIPSNAP, C. elegans, homolog 1 [BC006473], nucleolar and coiled-body phosphoprotein [AL553791], platelet-derived growth factor receptor, beta polypeptide [BI755841], procollagen-lysine, 2-oxogutarate 5-dioxygenase 3 [AL544817], proliferating cell nuclear antigen [AA523378], proliferation-associated 2G4, 38KD [BI088072], protein C receptor, endothelial (EPCR) [BG831881], pyruvate kinase, muscle [BF690275], rhoG [BG338917], regulatory factor X, 5 [AW027312], ribosomal protein L23 [AI349581], ribosomal protein L35 [BF310946], ribosomal protein L37 [BG032793], ribosomal protein S16 [BG765030], ribosomal protein S3 [AA593872], S100 calcium-binding protein A4 [AV713821], serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin) [BG567810], sigma receptor (SR31747 binding protein 1) [AL571572], small inducible cytokine subfamily A (Cys-Cys), member 19 [W07401], superoxide dismutase 2, mitochondrial [BG773219], survival of motor neuron 1, telomeric [AA029190], thymosin, beta 10 [AV707021], thyroid hormone receptor interactor 10 [N98668], transKetolase [BI195990], translocase of outer mitochondrial membrane 34 [BE798732], trefoil factor 3 (intestinal) [AA633399], tumor suppressing subtransferable candidate 3 [BE670374], zinc finger protein 267 [AU128446]

[ ]: GeneBank accession number