MORT1/FADD is involved in liver regeneration

Figure 1 Retarded liver regeneration in dnFADD mice. A: Onset of DNA synthesis was delayed in transgenic animals; after 36 h of PH, the amount of BrdU-positive cells was significantly smaller compared to wild-type animals, while the numbers did not differ significantly later on; B: Showing a markedly higher number of mitosis per high power field in wild-type animals after 48 h (^aP<0.05); C: Cyclin A protein expression was not detectable in transgenic animals whereas, detectable in wild-type animals at 36 h after hepatectomy. D: Onset of liver mass restoration was retarded in transgenic animals (^aP<0.05) but surviving mice reached around 90% of the pre-operative volume as did wild-type animals. The average immediate postoperative liver volumes in the wild-type and transgenic group were 49% and 48% of the preoperative liver volume, respectively. E: MRI scans were used to determine liver mass during regeneration.