Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis

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Dec 14, 2005 (publication date) through Oct 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2005; 11(46): 7323-7329
Published online Dec 14, 2005. doi: 10.3748/wjg.v11.i46.7323

Table 4 Frequencies of TLR9 haplotypes formed by -1237 T>C and +2848 G>A SNPs

TLR9 -1237	+2848	Haplotype	Controls	No pouchitis	Infrequent pouchitis	Chronic relapsing pouchitis
			2n = 448	2n = 158	2n = 86	2n = 70
T	G	I	181 (40)	51 (32)	40 (47)	28 (40)
T	A	II	195 (44)	77 (49)	37 (43)	24 (34)
C	A	III	69 (15)	29 (18)	9 (10)¹	18 (26)¹
C	G	IV	3 (1)	1 (1)	0	0

¹P = 0.018, OR = 3.0, 95%CI = 1.2-7.1.

Citation: Lammers K, Ouburg S, Morré S, Crusius J, Gionchetti P, Rizzello F, Morselli C, Caramelli E, Conte R, Poggioli G, Campieri M, Peña A. Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis. World J Gastroenterol 2005; 11(46): 7323-7329
URL: https://www.wjgnet.com/1007-9327/full/v11/i46/7323.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i46.7323