Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis

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Dec 14, 2005 (publication date) through Oct 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2005; 11(46): 7323-7329
Published online Dec 14, 2005. doi: 10.3748/wjg.v11.i46.7323

Table 3 Genotypes of the CD14, CARD15, TLR4, TLR9, and IRAKM gene polymorphisms in subgroups of patients with IPAA and controls

Polymorphisms	Genotype	Controls	No pouchitis	Infrequent pouchitis	Chronic relapsing pouchitis
		n = 224 (%)	n = 79 (%)	n = 43 (%)	n = 35 (%)
CD14–260 C>T	CC	55 (24.6)	24 (30.4)	11 (25.6)	7 (20)
	CT	102 (45.5)	34 (43)	21 (48.8)	22 (62.9)
	TT	67 (29.9)	21 (26.6)	11 (25.6)	6 (17.1)
CARD15 3020InsC	WT/WT	218 (97.3)	77 (97.5)	43 (100)	34 (97.1)
	WT/InsC	6 (2.7)	2 (2.5)	0 (0)	1 (2.9)
	InsC/InsC	0 (0)	0 (0)	0 (0)	0 (0)
TLR4 +896 A>G	AA	208 (92.9)	73 (92.4)	38 (88.4)	33 (94.3)
	AG	16 (7.1)	5 (6.3)	5 (11.6)	2 (5.7)
	GG	0 (0)	1 (1.3)	0 (0)	0 (0)
TLR9–1237 T>C	TT	158 (70.5)	52 (65.8)	34 (79.1)	19 (54.3)
	TC	60 (26.8)	24 (30.4)	9 (20.9)	14 (40)
	CC	6 (2.7)	3 (3.8)	0 (0)	2 (5.7)
TLR9 +2848 G>A	GG	40 (17.9)	20 (25.3)	9 (20.9)	6 (17.1)
	GA	104 (46.4)	38 (48.1)	22 (51.2)	16 (45.7)
	AA	80 (35.7)	21 (26.6)	12 (27.9)	13 (37.2)
IRAKM +22148G>A	GG	181 (80.8)	64 (81)	33 (76.7)	28 (80)
	GA	42 (18.8)	14 (17.7)	7 (16.3)	7 (20)
	AA	1 (0.4)	1 (1.3)	3 (7)	0 (0)

Citation: Lammers K, Ouburg S, Morré S, Crusius J, Gionchetti P, Rizzello F, Morselli C, Caramelli E, Conte R, Poggioli G, Campieri M, Peña A. Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis. World J Gastroenterol 2005; 11(46): 7323-7329
URL: https://www.wjgnet.com/1007-9327/full/v11/i46/7323.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i46.7323