Synergistic action of famotidine and chlorpheniramine on acetic acid-induced chronic gastric ulcer in rats

Table 1 Effects of combined famotidine (FMD) and chlorpheniramine (CPA) on the ulcerated area in different groups (mean±SD)

Group	Dose (mg/kg)	Area of ulcer (mm2)	6-keto-PGF1a (ng/L)	IL-8 (ng/L)	MPO (µ/L)
Blank		0	22.74±5.03	0.3±0.09	3.13±0.39
Control		40.18±2.6b	7.55±1.65b	0.69±0.11b	9.12±2.05b
FMD	4	32.9±3.27d	13.15±1.48d	0.51±0.08d	8.3±1.29
CPA	10	35.15±3.0d	10.79±1.48c	0.41±0.07d	5.7±1.00d
FMD+CPA	4+10	6.83±2.97df	16.62±0.97de	0.4±0.04 de	4.33±0.95df

^aP<0.05;

^bP<0.01 vs blank;

^cP<0.05;

^dP<0.01 vs control;

^eP<0.05;

^fP<0.01 vs FMD.