Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis

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Dec 7, 2005 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2005; 11(45): 7063-7071
Published online Dec 7, 2005. doi: 10.3748/wjg.v11.i45.7063

Table 5 Relation between p53 and H pylori and gastric mucosal change (tentative opinion)

Condition	Human	Japanesemonkey	Mongoliangerbil
H pylori and p53	++	++	+¹
overexpression (histology)
H pylori and p53 point mutation	++	++	-
H pylori and atrophic gastritis	++	++	++
H pylori and intestinal metaplasia	++	-	++
H pylori and gastric cancer	+²	-	++

¹The p53 overexpression was observed only in gastric cancer;

²Not proven by interventional study; ++, strong evidence; +, weak evidence; -, no evidence

Citation: Kodama M, Murakami K, Sato R, Okimoto T, Nishizono A, Fujioka T. Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis. World J Gastroenterol 2005; 11(45): 7063-7071
URL: https://www.wjgnet.com/1007-9327/full/v11/i45/7063.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i45.7063