Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis

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Dec 7, 2005 (publication date) through Jan 23, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2005; 11(45): 7063-7071
Published online Dec 7, 2005. doi: 10.3748/wjg.v11.i45.7063

Table 2 Gastric carcinogenesis in Helicobacter pylori-infected Mongolian gerbils

Author	Year	Strain	Study design (ppm)	Incidence ofcancer (%)	Duration ofexperiment (wk)
Sugiyama et al.	1998	ATCC43504	HP→MNU (10) HP alone MNU (30) → HP MNU alone	7/19 (36.8) 0/20 (0) 6/18 (33.3) 0/74 (0)	40 40 40 40
Tokieda et al.	1999	ATCC43504	HP → MNNG (50) persistent HP positive HP eradicated Br → MNNG (50)	5/17 (29.4) 5/8 (62.5) 0/9 (0) 3/22 (13.6)	52 52 52 50
Shimizu et al.	1999	ATCC43504	MNNG (300) → HP MNNG (300) → Br MNNG (60) → HP MNNG (60) → Br HP → MNNG (100) Br → MNNG (100) HP → MNNG (20) Br → MNNG (20) HP alone	12/27 (44.4) 1/19 (5.3) 6/25 (24.0) 0/20 (0) 4/27 (14.8) 3/18 (16.7) 15/25 (60) 1/20 (5) 0/20 (0)	50 50 50 50 50 50 50 50 50

HP, Helicobacter pylori; MNU, N-methyl-N-nitrosourea; MNNG, N-methyl-N’-nitroso-N-nitrosoguanidine; Br, Brucella broth.

Citation: Kodama M, Murakami K, Sato R, Okimoto T, Nishizono A, Fujioka T. Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis. World J Gastroenterol 2005; 11(45): 7063-7071
URL: https://www.wjgnet.com/1007-9327/full/v11/i45/7063.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i45.7063