Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model

Figure 5 MRI detection of tumor growth of orthotopically implanted MH SuperCD hepatomas treated under a low-dose 5-FC regimen. Animals #7, #8, #9 (column 1: tumor size at d 21), which first had been treated with saline only for over a 7-d period and thereafter, uniformly exhibiting a substantial tumor growth (column 2: tumor size at d 31), were then treated by a low-dose 5-FC regimen [twice weekly ip injections of 5-FC (283 mg/kg body weight)] over a 28-d period until d 59. Analysis of subsequent MRI sections did not reveal any MH SuperCD tumors (column 3, d 59: +low dose 5-FC); T2 weighed images are depicted; arrows in column 3 point out to places of former tumor localizations before the onset of 5-FC treatment.