MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells

Figure 2 A: Cell viability of P-3EV and Px14 cell lines after 24 h of gemcitabine treatment at various concentrations. Gemcitabine reduced cell viability in a dose-dependent manner. At a concentration of 0.1 μg/mL or above, Px14 cells exhibited higher viability relative to P-3EV cells (one-way ANOVA, n = 3, ^aP<0.05 vs others); B: Hoechst staining of P-3EV and Px14 cell lines. After 24 h of gemcitabine treatment at a concentration of 1 μg/mL, apoptotic changes (nuclear chromatin condensation and nuclear fragmentation) were obviously observed in P-3EV cells (arrow), but not in Px14 cells.