Relation of overexpression of S phase kinase-associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma

Table 1 Skp2 protein expression in human gastric tissues

frequency(%)	Specimens	Skp2 labeling frequency(%)
Tissue	(n)	Median	Mean±SE
Normal gastric mucosa	5	0.001	0.47±0.19
Chronic superficial gastritis	10	0.002	0.53±0.13
Intestinal metaplasia	30	12.003	12.68±0.86
Dysplasia	30	19.004	16.74±0.82
Primary gastric carcinoma	138	29.005	31.34±2.17
Adjacent mucosa	138	16.006	19.32±1.22
Metastasis tumor tissue in lymph node	102	39.507	39.76±2.00

^{1,2 ,3 ,4}Frequency was significantly higher than in normal gastric tissue and chronic superficial gastritis (P = 0.000,all the same; Mann-Whitney U test). ²Frequency was significantly higher than in intestinal metaplasia (P = 0.000; Mann-Whitney U test). ³Frequency was significantly higher than in intestinal metaplasia and dysplasia, (P = 0.000,all the same; Mann-Whitney U test). ⁵Frequency was Significantly higher than in primary tumors (P = 0.037; Mann-Whitney U test).