Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer

Table 2 Association between XRCC1 and XRCC3 genotype profiles and risk for chronic gastritis (CG) and gastric cancer (GC)

XRCC1		XRCC3	Groups
Codon 194	Codon 399	Codon 241	CG	GC	OR (95%CI) P	CG	C1	OR (95%CI) P	GC	C2	OR (95%CI) P
All wide-type genotypes
Arg	Arg	Thr	33	32	1.0 (reference)	33	34	1.0 (reference)	32	23	1.0 (reference)
One variant polymorphism
Trp	Arg	Thr	5	8	0.6 (0.17-2.04) 0.5469	5	6	1.2 (0.32-4.16) 1.0000	8	6	1.1 (0.32-3.44) 1.0000
Arg	Gln	Thr	51	38	1.4 (0.68-2.50) 0.5124	51	42	0.8 (0.42-1.51) 0.5234	38	34	1.2 (0.61-2.56) 0.5918
Arg	Arg	Met	50	27	2.0 (0.91-3.57) 0.1237	50	49	1.0 (0.51-1.75) 1.0000	27	34	2,0 (0.83-3.70) 0.1426
Two variant polymorphisms
Trp	Gln	Thr	3	5	0.6 (0.13-2.63) 0.7106	3	2	0.6 (0.1-4.16) 1.0000	5	4	1.1 (0.16-4.54) 1.0000
Arg	Gln	Met	43	43	1.0 (0.50-1.85) 1.0000	43	58	1.4 (0.69-2.43) 0.4309	43	39	1.2 (0.63-2.50) 0.5389
Trp	Arg	Met	10	6	1.6 (0.52-5.00) 0.5771	10	6	0.6 (0.19-1.78) 0.4106	6	7	1.6 (0.48-5.55) 0.5999
Three variant polymorphisms
Trp	Gln	Met	8	1	8.3 (0.91-100) 0.0372	8	5	0.6 (0.17-2.04) 0.5400	1	3	5.0 (0.40-50.0) 0.3113