Immunological treatment of liver tumors

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Nov 14, 2005 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2005; 11(42): 6571-6576
Published online Nov 14, 2005. doi: 10.3748/wjg.v11.i42.6571

Table 2 Commonest viruses used as gene therapy vectors

Retroviruses	Adenoviruses	Adeno-associated virus (AAV)	Herpes virus
8kb, RNA enveloped	35 kb, DNA, non-enveloped	5 kb, single stranded DNA, non-enveloped	61 kb, double-stranded DNA
Activate proto-oncogene by insertional mutagenesis	Episomal, transient	Stable integration, high infectivity	Infect mainly neurons
Cause lymphoma	Highly immunogenic, causing inflammation and anaphylactic shock	Non-pathogenic; requires helper viruses such as Adenoviruses for replication and packaging in mammalian cells.	Cause cold sores or blisters in the genital areas
Inactivation of transgene in vivo	One case of death	Long-term expression in vivo	Cutaneous skin lesions

Citation: Chiriva-Internati M, Grizzi F, Jumper CA, Cobos E, Hermonat PL, Frezza EE. Immunological treatment of liver tumors. World J Gastroenterol 2005; 11(42): 6571-6576
URL: https://www.wjgnet.com/1007-9327/full/v11/i42/6571.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i42.6571