Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model

Figure 5 Effect of spinal CNQX on average responses of LS neurons to CRD. Bar graphs illustrate the responses of LS neurons to graded CRD (20-80 mmHg) recorded in control rats (A; left panel) or CI rats (B; right panel) before and after spinal administration of CNQX. A: In control rats, CNQX (5 µmoL) significantly attenuated the responses to CRD in the 40-80 mmHg range and CNQX (10 µmoL) significantly attenuated the response to all intensities of CRD; B: In CI rats, CNQX (2-10 µmoL) significantly decreased the response to all intensities of CRD in a dose-dependent manner. ^aP<0.05, ^bP<0.01, ^dP<0.001 vs before CNQX application at that distention pressure in each group; ^cP <0.05 vs 2 µmoL CNQX.