Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

Figure 3 Effect of GSE (32 mg/kg ig) on the mean number of WRS-induced gastric lesions and accompanying alterations in the gastric mucosal PGE2 generation and GBF in rats with or without the pretreatment with indomethacin (5mg/kg ip) or rofecoxib (10 mg/kg ig). Results are mean±SE from 6 to 8 animals per group. ^aP<0.05 vs vehicle (Veh), ^cP<0.05 vs respective values in animals without indomethacin or rofecoxib pretreatment.