Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model

Table 1 Percentage attenuation of responses to graded CRD of LS neurons by AP-7 in control and CI rats

Dose	20 (%)	40 (%)	60 (%)	80 (mmHg%)
Controls
0.001 mmoL	25 (4/16)	25 (4/16)	25 (4/16)	25 (4/16)
0.01 mmoL	36.3 (4/11)	36.3 (4/11)	36.3 (4/11)	45.4 (5/11)
0.1 mmoL	41.6 (5/12)	50 (6/12)	58.3 (7/12)	75 (9/12)
1 mmoL	50 (8/16)	50 (8/16)	50 (8/16)	81.2 (13/16)
CI rats
0.001 mmoL	40 (6/15)	40 (6/15)	40(6/15)	40 (6/15)
0.01 mmoL	60 (6/10)	60 (6/10)	60 (6/10)	60 (6/10)
0.1 mmoL	81.8 (9/11)	81.8 (9/11)	81.8 (9/11)	81.8 (9/11)
1 mmoL	100 (9/9)	100 (9/9)	100 (9/9)	100 (9/9)

Denominators in parentheses indicate the total number of LS neurons treated with AP-7 and numerators indicate the number of neurons affected by AP-7 at the same dose level in control and CI rats. A drug effect is described as a change by more than 20% in the response to CRD after the drug was applied, compared to baseline response recorded before the use of drug.